Lysolecithin inhibits an action of bee venom phospholipase A2in erythrocyte membrane

Inhibition of beta-bungarotoxin action by bee venom phospholipase A2.

(3-Bungarotoxin ((3-BuTX) induces twitching of innervated frog muscle and subsequently blocks transm itter release from motor nerve endings. These actions of P-BuTX are prevented if the nerve-muscle junctions are pretreated with a low concentration of phospholipase A2 from bee venom. When the Ca2+ in the external fluid is replaced by Sr2+, the phospho­ lipase activity of P-BuTX is negligible an...

Crystal structure of bee-venom phospholipase A2: correction.

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Phospholipase B in snake venoms and bee venom.

Bee Venom Phospholipase A2: Yesterday’s Enemy Becomes Today’s Friend

Bee venom therapy has been used to treat immune-related diseases such as arthritis for a long time. Recently, it has revealed that group III secretory phospholipase A2 from bee venom (bee venom group III sPLA2) has in vitro and in vivo immunomodulatory effects. A growing number of reports have demonstrated the therapeutic effects of bee venom group III sPLA2. Notably, new experimental data have...

Bee venom inhibits growth of human cervical tumors in mice

We studied whether bee venom (BV) inhibits cervical tumor growth through enhancement of death receptor (DR) expressions and inactivation of nuclear factor kappa B (NF-κB) in mice. In vivo study showed that BV (1 mg/kg) inhibited tumor growth. Similar inhibitory effects of BV on cancer growth in primary human cervical cancer cells were also found. BV (1-5 μg/ml) also inhibited the growth of canc...